This project investigated using systemic acquired resistance (SAR) and generally regarded as safe (GRAS) chemicals as part of an integrated programme to control the major diseases of rhubarb. SAR and GRAS chemicals have the advantage of having multiple modes of action and are not pathogen specific. As a result, several diseases can be controlled using the same chemicals and the risk of developing resistance is very low. This project was a preliminary study aimed at screening the use of the generally regarded as safe chemical called Milsana and the defence elicitor acibenzolar-S-methyl as methods of controlling leaf spot disease Ascochyta rhei in rhubarb. The project aimed to see if these chemicals induced systemic acquired resistance in rhubarb.