This report is a user guide for those considering the practical advancement and feasibility of regional biosecurity. It outlines the considerations, optional approaches, and cost-effective means to commencing and making progress. The On-far, Biosecurity Manual for NAP vegetable growers provides a ready-to-use guide to the threats the region is facing, and should be read in conjunction with this report. The identified threats are considered in the framework design and range, options presented and in the discussion of feasible approaches for adding value to existing activities.